Interesting....
Now I think about it, Bryan's stat setup I heard last year and was really impressed with, was using a Tram2 DHT preamp which is an OTL design. Then plugged into the custom OTL power amp. The system had a very raw, powerful, dynamic, 'direct' type sound. I did like it.
Low powered SE OTL amp to drive some horn loaded drivers could be interesting. Might be too much of a 'good' thing though.